Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	S84A	-	Target modification, DNA gyrase subunit A GyrA	Staphylococcus aureus, Staphylococcus pseudintermedius	levofloxacinmoxifloxacinfluoroquinolones+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase A	S84F	-	-	Staphylococcus epidermidis, Streptococcus pneumoniae, Haemophilus parainfluenzae, non-typeable Haemophilus, Staphylococcus cohnii, Staphylococcus condimenti, Enterococcus faecalis, Salmonella pullorum	ciprofloxacinofloxacingatifloxacin+5 more	Reslit	Supported
gyrA DNA gyrase subunit A	S84I	-	-	Enterococcus faecalis, Corynebacterium sp.	ciprofloxacinnorfloxacinmoxifloxacin+5 more	Reslit	Supported
gyrA DNA gyrase A subunit	S84K	-	-	Staphylococcus aureus, Streptococcus pneumoniae	quinolones	Reslit	Candidate
gyrA DNA gyrase A subunit	S84L	T252C TCA -> TTG T251C AGT->TTT TCA->CTA C251T AGC->CTC G251T	reduced potency of ciprofloxacin, decreased binding affinity of ciprofloxacin to its target, confers resistance, resistance, mutation in GyrA confers resistance to ciprofloxacin, fluoroquinolone resistance, mutations in QRDRs, Target modification, single resistance variant, DNA gyrase subunit A GyrA	Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus simulans, Staphylococcus aureus, Staphylococcus pseudintermedius, Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus agnetis, Staphylococcus chromogenes, Staphylococcus arlettae, Staphylococcus lentus, Moraxella catarrhalis, Haemophilus quentini, Haemophilus haemolyticus, Staphylococcus sciuri, Staphylococcus cohnii, Staphylococcus condimenti, Staphylococcus gallinarum, Staphylococcus saprophyticus, Staphylococcus ureilyticus, Staphylococcus warneri, Staphylococcus xylosus, S. haemolyticus	ciprofloxacinquinolonesfluoroquinolones+13 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	S84P	-	-	Mycoplasma salivarium	quinoloneslevofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S84R	-	-	Enterococcus faecalis, Enterococcus faecium	levofloxacinmoxifloxacinofloxacin+1 more	Reslit	Supported
gyrA	S84V	-	DNA gyrase subunit A GyrA	Staphylococcus aureus	quinolones	Reference Gene Catalog	Established
gyrA	S84W	-	DNA gyrase subunit A GyrA	Staphylococcus pseudintermedius	quinolones	Reference Gene Catalog	Established
gyrA DNA gyrase A	S84Y	-	single resistance variant, DNA gyrase subunit A GyrA	Staphylococcus epidermidis, Streptococcus pneumoniae, Haemophilus parainfluenzae, Haemophilus influenzae	ciprofloxacinofloxacingatifloxacin+6 more	Card DatabaseReference Gene CatalogReslit	Confirmed