Prevalence and molecular analysis of macrolide and fluoroquinolone resistance among isolates of Streptococcus pneumoniae collected during the 2000-2001 PROTEKT US Study.

PMID: 155286842004United States

Key Findings

The study identified mef(A) and erm(B) as the predominant macrolide resistance genes in Streptococcus pneumoniae isolates, and multiple mutations in gyrA, parC, and parE as the main mechanisms of fluoroquinolone resistance.

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2gene entries

10mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
erm(B)	1	methyltransferase	MacrolideLincosamideStreptogramin b	Streptococcus pneumoniae	Reslit	-
mef(A)	1	efflux pump	Macrolide	Streptococcus pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	S79R	-	-	Streptococcus pneumoniae	Fluoroquinolones	Reslit	-
parC	Q90H	-	-	Streptococcus pneumoniae	Fluoroquinolones	Reslit	-
parC	S79F	-	-	Streptococcus pneumoniae	Fluoroquinolones	Reslit

Browse Papers

Prevalence and molecular analysis of macrolide and fluoroquinolone resistance among isolates of Streptococcus pneumoniae collected during the 2000-2001 PROTEKT US Study.

AMR Genes

AMR Mutations