Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.

PMID: 219663962011China

Key Findings

The study identifies multiple AMR genes and mutations in the multidrug-resistant S. suis R61 strain, including pbp2x, pbp2b, gyrA, parC, tet(W), and mef(E), contributing to resistance against β-lactams, quinolones, tetracyclines, and macrolides.

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4gene entries

5mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mef(En2)	1	efflux pump	ErythromycinAzithromycin	Streptococcus suis	Reslit	-
pbp2b	1	penicillin-binding protein	AmpicillinPenicillinCefotaximeCeftriaxoneCefuroximeCefaclor	Streptococcus suis	Reslit

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp2x	T489S	A1466G	-	-	Ampicillin\|Penicillin\|Cefotaxime\|Ceftriaxone\|Cefuroxime\|Cefaclor	Reslit	-
pbp2x	T491S	A1472G	-	-	Ampicillin\|Penicillin\|Cefotaxime\|Ceftriaxone\|Cefuroxime\|Cefaclor	Reslit	-
pbp2x	A492V	G1475T

Browse Papers

Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.

AMR Genes

AMR Mutations