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Key Findings
Mutations in pncA were associated with pyrazinamide resistance.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| G162S | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| L511P | - | - | - | Levofloxacin | Reslit | - | |
| I572F | - | - | Mycobacterium tuberculosis | Rifampin | Reslit | - | |
| G17D | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| D516Y | - | - | - | Levofloxacin | Reslit | - | |
| S17N | - | - | - | Isoniazid | Reslit | - | |
| T168I | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| H526S | - | - | - | Levofloxacin | Reslit | - | |
| G206S | - | - | - | Isoniazid | Reslit | - | |
| G132D | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| W571G | - | - | - | Levofloxacin | Reslit | - | |
| E340Q | - | - | - | Isoniazid | Reslit | - | |
| V147I | - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - |
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