Key Findings

The study identifies bla CTX-M-15 as the most prevalent ESBL gene in third-generation cephalosporin-resistant Enterobacteriaceae in the Netherlands, along with various other ESBL and AmpC genes such as bla CTX-M-1, bla CTX-M-14, bla SHV-12, bla TEM-52, and bla CMY-2. Mutations in the promoter region of the chromosomal ampC gene were also found to contribute to resistance.