Chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms among broad-spectrum-cephalosporin-resistant Escherichia coli isolates recovered from companion animals in the USA.

PMID: 233025782013USA

Key Findings

The study identified plasmid-mediated quinolone resistance (PMQR) determinants aac(6')-Ib-cr, qnrS, and qepA, along with novel mutations in topoisomerase genes gyrA, parC, and parE contributing to fluoroquinolone resistance in Escherichia coli isolates from companion animals.

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2gene entries

7mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
qepA	1	efflux pump	Ciprofloxacin	Escherichia coli	Reslit	-
qnrS	1	quinoxaline resistance protein	Ciprofloxacin	Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S83L	-	-	Escherichia coli	Ciprofloxacin	Reslit	-
parE	R432S	-	-	Escherichia coli	Ciprofloxacin	Reslit	-
parC	L88Q	-	-	Escherichia coli	Ciprofloxacin	Reslit

Browse Papers

Chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms among broad-spectrum-cephalosporin-resistant Escherichia coli isolates recovered from companion animals in the USA.

AMR Genes

AMR Mutations