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Explore scientific publications on antimicrobial resistance
Explore scientific publications on antimicrobial resistance
Key Findings
The study identified multiple S. Typhi genotypes in Nigeria, with a focus on antimicrobial resistance genes and plasmids. Key resistance genes included blaTEM-1, catA1, tetB, dfrA15, sul1, sul2, strAB, aad, and qnrS, primarily associated with the IncHI1 plasmid. Quinolone resistance was linked to gyrA mutations S83Y and S83F.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aad9 | 1 | aminoglycoside adenylyltransferase | Streptomycin |
| Reslit | - |
| blaTEM | 1 | beta-lactamase | Ampicillin |
| Reslit | - |
| dfrA15 | 1 | dihydrofolate reductase | Trimethoprim |
|
Reslit |
| - |
| qnrS | 1 | quinolone resistance protein | Fluoroquinolone |
| Reslit | - |
| sul1 | 1 | sulfonamide resistance protein | Sulfamethoxazole |
| Reslit | - |
| sul2 | 1 | sulfonamide resistance protein | Sulfamethoxazole |
| Reslit | - |
| tetB | 1 | tetracycline efflux pump | Tetracycline |
| Reslit | - |
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