A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.

PMID: 281378042017Costa Rica

Key Findings

The study identifies multiple AMR genes and mutations contributing to multidrug resistance in a Clostridium difficile lineage endemic to Costa Rican hospitals, including ermB, tetM, catD, aacA-aphD, and ant6-sat4-aphA-3, as well as gyrA and rpoB mutations.

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4gene entries

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
aacA-aphD	1	aminoglycoside modifying enzyme	GentamicinKanamycinNeomycin	Clostridium difficile	Reslit	-
catD	1	chloramphenicol acetyltransferase	Chloramphenicol	Clostridium difficile	Reslit	-
erm(B)	1	ribosomal protection protein

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	T82I	-	fluoroquinolone resistance	Clostridium difficile	Ciprofloxacin\|Levofloxacin\|Moxifloxacin	Reslit	-
rpoB	R505K	-	-	Mycobacterium tuberculosis	Rifampin	Reslit	-
rpoB	H502N	-	-	Mycobacterium tuberculosis	Rifampin	Reslit

Browse Papers

A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.

AMR Genes

AMR Mutations