Key Findings

The study compared culture-based and molecular-based susceptibility testing for six antibiotics in H. pylori using clinical isolates and formalin-fixed, paraffin-embedded gastric biopsies. It found that next-generation sequencing accurately predicted resistance to clarithromycin, levofloxacin, rifabutin, and tetracycline, while showing fair agreement for metronidazole and amoxicillin.