Key Findings

The study identifies genes and mutations associated with synergy between polymyxin B and minocycline or rifampin against E. coli producing NDM and OXA-48-group carbapenemases. Key findings include the tetracycline efflux gene tet(B), lipid A biosynthesis genes lpxK and eptA, and the lipid A modifying enzyme arnT as being associated with synergy.