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Key Findings
The study identified mutations in 23S rRNA, rplD, parC, gyrB, and parE genes associated with erythromycin, tetracycline, and levofloxacin resistance in Ureaplasma isolates. The tet(M) gene was detected in tetracycline-resistant isolates, and specific mutations in parC and gyrB were linked to fluoroquinolone resistance.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| tet(M) | 1 | tetracycline resistance determinant | Tetracycline |
| Reslit | - |
| - |
| A588G | - | - | Ureaplasma parvum, Ureaplasma urealyticum | Erythromycin | Reslit | - |
| T96C | - | - | Ureaplasma parvum, Ureaplasma urealyticum | Levofloxacin | Reslit | - |
| P462S | - | - | - | Levofloxacin | Reslit | - |
| V417T | - | - | Ureaplasma parvum, Ureaplasma urealyticum | Levofloxacin | Reslit | - |
| E482G | - | - | - | Levofloxacin | Reslit | - |
| E87K | - | - | Ureaplasma urealyticum, Ureaplasma parvum | Levofloxacin | Reslit | - |
| T85A | - | - | Ureaplasma urealyticum, Ureaplasma parvum | Levofloxacin | Reslit | - |
| D426N | - | - | Ureaplasma urealyticum, Ureaplasma parvum | Levofloxacin | Reslit | - |
| D443N | - | - | - | Levofloxacin | Reslit | - |
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