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Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance.

PMID: 159803662005

Key Findings

Mutations T338A, Q552E, M339F, and M400T in PBP 2x are associated with reduced susceptibility to penicillin G and cefotaxime.

0gene entries

12mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp2x	T338A	A1012G	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2b	T446A	A1336G	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2b	E476G	A1427G	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2b	T489S	A1466T	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp1b	R526S	A1579T	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp1b	M527L	A1580C	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	M400T	ATG->ACT	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	M339F	ATG->TTT	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp1b	N531K	C1595A	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	Q552E	C1654G	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2a	G425S	G1273A	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2a	D440N	G1320A	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-