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Key Findings
Rifampicin-resistant Mycobacterium tuberculosis strains exhibit reduced susceptibility to ofloxacin through the activation of efflux pumps. Specific efflux-related genes such as Rv3239c, Rv1258c, Rv2333c, Rv1877, Rv2994, Rv1634, Rv1747, whiB7, and Rv1002c were upregulated upon rifampicin exposure, contributing to ofloxacin resistance.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| Rv1002c | 1 | conserved membrane protein predicted to be in the GT-C superfamily of glycosyltransferases | Ofloxacin |
| Reslit | - |
| Rv1258c | 1 | probable conserved integral membrane transport (efflux) protein | Ofloxacin |
| Reslit | - |
| Rv1634 | 1 | possible drug efflux membrane protein | Ofloxacin |
Reslit |
| - |
| Rv1747 | 1 | probable conserved transmembrane ATP-binding protein ABC transporter | Ofloxacin |
| Reslit | - |
| Rv1877 | 1 | probable conserved integral membrane protein | - |
| Reslit | - |
| Rv2994 | 1 | probable conserved integral membrane protein | Ofloxacin |
| Reslit | - |
| Rv3239c | 1 | probable transmembrane protein | Ofloxacin |
| Reslit | - |
| whiB7 | 1 | WhiB-like and MDR effector gene | Ofloxacin |
| Reslit | - |
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