Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer.

PMID: 330078232020

Key Findings

The study identifies resistance mechanisms in commensal Neisseria species, including the presence of blaTEM-1, tetM, and gyrA mutations, which can be horizontally transferred to N. gonorrhoeae.

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2gene entries

13mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaTEM	1	beta-lactamase	Penicillin	Neisseria gonorrhoeae Moraxella catarrhalis	Reslit	-
tet(M)	1	tetracycline resistance protein	Tetracycline	Neisseria gonorrhoeae Neisseria subflava	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
porB	G120K	-	-	Neisseria gonorrhoeae, Neisseria subflava	Tetracycline	Reslit	-
rpsJ	V57M	-	-	Neisseria gonorrhoeae, Neisseria subflava	Tetracycline	Reslit	-
gyrA	S91F	-	-	Neisseria gonorrhoeae, Neisseria bacilliformis	Ciprofloxacin	Reslit

Browse Papers

Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer.

AMR Genes

AMR Mutations