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Efflux Pump-Driven Antibiotic and Biocide Cross-Resistance in Pseudomonas aeruginosa Isolated from Different Ecological Niches: A Case Study in the Development of Multidrug Resistance in Environmental Hotspots.

PMID: 331142772020

Key Findings

mutations in nalC lead to overexpression of mexAB-oprM

0gene entries

12mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
nalC	G71E	-	mutations in regulators MexR, NalC, or NalD	Pseudomonas aeruginosa	Fluoroquinolones\|Cephalosporin\|Aminoglycoside	Reslit	-
parC	S87L	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
nalC	S209R	-	mutations in regulators MexR, NalC, or NalD	Pseudomonas aeruginosa	Fluoroquinolones\|Cephalosporin\|Aminoglycoside	Reslit	-
parC	V297I	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
mexR	V126E	-	mutations in regulators MexR, NalC, or NalD	Pseudomonas aeruginosa	Fluoroquinolones\|Cephalosporin\|Aminoglycoside	Reslit	-
gyrA	D87N	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
nalC	E153Q	-	mutations in regulators MexR, NalC, or NalD	Pseudomonas aeruginosa	Fluoroquinolones\|Cephalosporin\|Aminoglycoside	Reslit	-
parE	D533E	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
nalD	T11N	-	mutations in regulators MexR, NalC, or NalD	Pseudomonas aeruginosa	Fluoroquinolones\|Cephalosporin\|Aminoglycoside	Reslit	-
gyrB	E468D	-	-	-	Fluoroquinolones	Reslit	-
gyrA	T83I	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
gyrB	H148N	-	-	-	Fluoroquinolones	Reslit	-