Overexpression of Efflux Pumps, Mutations in the Pumps' Regulators, Chromosomal Mutations, and AAC(6′)-Ib-cr Are Associated With Fluoroquinolone Resistance in Diverse Sequence Types of Neonatal Septicaemic Acinetobacter baumannii: A 7-Year Single Center Study.

PMID: 337769502021India|Kenya

Key Findings

The study identifies aac(6')-Ib-cr as a significant contributor to fluoroquinolone resistance in Acinetobacter baumannii, alongside chromosomal mutations in gyrA and parC, and overexpression of efflux pumps regulated by adeR and adeS.

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4gene entries

12mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
abeM	1	efflux pump	Fluoroquinolone	Acinetobacter baumannii	Reslit	-
adeB	1	efflux pump	Fluoroquinolone	Acinetobacter baumannii	Reslit	-
adeG	1	efflux pump	Fluoroquinolone	Acinetobacter baumannii

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S91L	-	-	Acinetobacter baumannii	Ciprofloxacin	Reslit	-
adeR	I228V	-	-	Acinetobacter baumannii	Fluoroquinolones	Reslit	-
adeS	E121K	-	-	Acinetobacter baumannii	Fluoroquinolones	Reslit

Browse Papers

Overexpression of Efflux Pumps, Mutations in the Pumps' Regulators, Chromosomal Mutations, and AAC(6′)-Ib-cr Are Associated With Fluoroquinolone Resistance in Diverse Sequence Types of Neonatal Septicaemic Acinetobacter baumannii: A 7-Year Single Center Study.

AMR Genes

AMR Mutations