Leveraging large-scale Mycobacterium tuberculosis whole genome sequence data to characterise drug-resistant mutations using machine learning and statistical approaches.

PMID: 395113092024Europe|Africa|South East Asia|Western Pacific|Americas

Key Findings

The study identifies several genes and mutations associated with drug resistance in Mycobacterium tuberculosis, including pncA, ethA, ndh, mshA, embR, rpoB, inhA, gyrA, and Rv0678, along with their respective mutations that confer resistance to pyrazinamide, ethionamide, isoniazid, rifampicin, ethambutol, fluoroquinolones, bedaquiline, and clofazimine.

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5gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
embR	1	embryonic protein R	Ethambutol	Mycobacterium tuberculosis	Reslit	-
ethA	1	ethionamide monooxygenase	Ethionamide	Mycobacterium tuberculosis	Reslit	-
mshA	1	mycothiol synthase

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	D280G	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
rpoB	P230L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-

Browse Papers

Leveraging large-scale Mycobacterium tuberculosis whole genome sequence data to characterise drug-resistant mutations using machine learning and statistical approaches.

AMR Genes

AMR Mutations