Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis.

PMID: 400076072025

Key Findings

The threonine-to-asparagine substitution at position 491 in PBP1B leads to a shift in substrate preference from D-Ala-D-Ala to D-Ala-D-Lac.

0gene entries

37mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp1b	T491N	-	shift in substrate preference from D-Ala-D-Ala to D-Ala-D-Lac	Enterococcus faecalis	Vancomycin	Reslit	-
pbp3	A353S	-	-	-	Vancomycin	Reslit	-
pbp3	T372Q	-	-	-	Vancomycin	Reslit	-
pbp3	N385R	-	-	-	Vancomycin	Reslit	-
pbp3	T393N	-	-	-	Vancomycin	Reslit	-
pbp3	V419M	-	-	-	Vancomycin	Reslit	-
pbp3	T440A	-	-	-	Vancomycin	Reslit	-
pbp3	N453M	-	-	-	Vancomycin	Reslit	-
pbp3	S350T	-	-	-	Vancomycin	Reslit	-
pbp3	I368V	-	-	-	Vancomycin	Reslit	-
pbp3	G384T	-	-	-	Vancomycin	Reslit	-
pbp3	S391T	-	-	-	Vancomycin	Reslit	-
pbp3	D416E	-	-	-	Vancomycin	Reslit	-
pbp3	H439S	-	-	-	Vancomycin	Reslit	-
pbp3	I448F	-	-	-	Vancomycin	Reslit	-
pbp2a	K336G	-	-	Enterococcus faecalis	Vancomycin	Reslit	-
pbp3	I354M	-	-	-	Vancomycin	Reslit	-
pbp3	T376V	-	-	-	Vancomycin	Reslit	-
pbp3	K387N	-	-	-	Vancomycin	Reslit	-
pbp3	N408K	-	-	-	Vancomycin	Reslit	-
pbp3	S429T	-	-	-	Vancomycin	Reslit	-
pbp3	D445G	-	-	-	Vancomycin	Reslit	-
pbp3	G460A	-	-	-	Vancomycin	Reslit	-
pbp3	N326D	-	-	-	Vancomycin	Reslit	-
pbp3	L359Q	-	-	-	Vancomycin	Reslit	-
pbp3	I378V	-	-	-	Vancomycin	Reslit	-
pbp3	D388G	-	-	-	Vancomycin	Reslit	-
pbp3	R412K	-	-	-	Vancomycin	Reslit	-
pbp3	T436S	-	-	-	Vancomycin	Reslit	-
pbp3	N446T	-	-	-	Vancomycin	Reslit	-
pbp3	L345I	-	-	-	Vancomycin	Reslit	-
pbp3	S364L	-	-	-	Vancomycin	Reslit	-
pbp3	V383Y	-	-	-	Vancomycin	Reslit	-
pbp3	T390E	-	-	-	Vancomycin	Reslit	-
pbp3	G415D	-	-	-	Vancomycin	Reslit	-
pbp3	S437G	-	-	-	Vancomycin	Reslit	-
pbp3	T447N	-	-	-	Vancomycin	Reslit	-