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Key Findings
The study identified various AMR genes in commensal E. coli from pigs, including blaTEM, catA1, aph(3')-Ia, aadA, strA/strB, tet(A), tet(B), sul1, sul2, and sul3. These genes conferred resistance to antibiotics such as ampicillin, chloramphenicol, kanamycin, neomycin, streptomycin, spectinomycin, tetracycline, and sulfamethoxazole. However, the presence of these resistance genes did not provide a significant colonization advantage or disadvantage in the pig intestine.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aadA | 1 | Amino glycoside adenyltransferase | StreptomycinSpectinomycin |
| Reslit | - |
| aadA2 | 1 | Streptomycin kinase | Streptomycin |
| Reslit | - |
| aph(3')-Ia |
| 1 |
| Aminoglycoside phosphotransferase |
KanamycinNeomycin |
|
Reslit |
| - |
| blaTEM | 1 | Beta-lactamase | Ampicillin |
| Reslit | - |
| catA1 | 1 | Chloramphenicol acetyltransferase | Chloramphenicol |
| Reslit | - |
| sul1 | 1 | Sulfonamide resistance protein | Sulfamethoxazole |
| Reslit | - |
| sul2 | 1 | Sulfonamide resistance protein | Sulfamethoxazole |
| Reslit | - |
| sul3 | 1 | Sulfonamide resistance protein | Sulfamethoxazole |
| Reslit | - |
| tet(A) | 1 | Tetracycline efflux pump | Tetracycline |
| Reslit | - |
| tet(B) | 1 | Tetracycline efflux pump | Tetracycline |
| Reslit | - |
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