Repression of invasion genes and decreased invasion in a high-level fluoroquinolone-resistant Salmonella typhimurium mutant.

PMID: 199463772009Europe|Spain

Key Findings

The study identifies three QRDR mutations in gyrA (D87G, G81C) and parE (E470K) that contribute to high-level fluoroquinolone resistance in Salmonella typhimurium. Overexpression of AcrAB/TolC efflux pump is also associated with resistance.

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2gene entries

8mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
acrab	1	acridine efflux pump	CiprofloxacinNorfloxacinNalidixic acid	Salmonella typhimurium	Reslit	-
tolC	1	outer membrane channel precursor protein	CiprofloxacinNorfloxacinNalidixic acid	Salmonella typhimurium	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	S80F	-	-	Salmonella typhimurium	Ciprofloxacin\|Nalidixic acid	Reslit	-
parE	E401K	-	-	Salmonella typhimurium	Ciprofloxacin	Reslit	-
gyrB	E466K	-	-	Salmonella typhimurium	Ciprofloxacin	Reslit

Browse Papers

Repression of invasion genes and decreased invasion in a high-level fluoroquinolone-resistant Salmonella typhimurium mutant.

AMR Genes

AMR Mutations