Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.

PMID: 320710602020

0gene entries

34mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	P308L	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
oprD	S278P	-	-	Pseudomonas aeruginosa	Carbapenem	Reslit	-
fusA1	D588G	-	-	Pseudomonas aeruginosa	Aminoglycoside	Reslit	-
PA4280.2	A2044G	-	-	Pseudomonas aeruginosa	Macrolide	Reslit	-
colR	D138N	-	-	Pseudomonas aeruginosa	Polymyxin	Reslit	-
parC	T705A	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
mexY	F1018L	-	-	Pseudomonas aeruginosa	Aminoglycoside\|Cefepime\|Fluoroquinolones	Reslit	-
fusA1	V338A	-	-	Pseudomonas aeruginosa	Aminoglycoside	Reslit	-
PA4280.2	C2597T	-	-	Pseudomonas aeruginosa	Macrolide	Reslit	-
colS	T138A	-	-	Pseudomonas aeruginosa	Polymyxin	Reslit	-
gyrA	D87G	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
parE	S492F	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
fusA1	V93A	-	-	Pseudomonas aeruginosa	Aminoglycoside	Reslit	-
fusA1	Y683C	-	-	Pseudomonas aeruginosa	Aminoglycoside	Reslit	-
parR	A45T	-	-	Pseudomonas aeruginosa	Polymyxin	Reslit	-
ampC	P154L	-	-	Pseudomonas aeruginosa	Cephalosporin\|Aztreonam	Reslit	-
parE	D462G	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
amgS	P116L	-	mutations in the sensor domain of AmgS, where mutations involved in aminoglycoside resistance have been previously described	Pseudomonas aeruginosa	Aminoglycoside	Reslit	-
fusA1	A595V	-	-	Pseudomonas aeruginosa	Aminoglycoside	Reslit	-
pmrB	T132A	-	-	Pseudomonas aeruginosa	Polymyxin	Reslit	-
parE	V199M	-	-	Pseudomonas aeruginosa	Fluoroquinolones	Reslit	-
amgS	A203V	-	mutations in the linker domain of AmgS, the closest Escherichia coli homolog of AmgS, often cause activation of the kinase sensor	Pseudomonas aeruginosa	Aminoglycoside	Reslit	-
fusA1	A481V	-	-	Pseudomonas aeruginosa	Aminoglycoside	Reslit	-
phoP	V30A	-	-	Pseudomonas aeruginosa	Polymyxin	Reslit	-
ftsI	H394R	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
ftsI	N427S	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
ftsI	Q458R	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
ftsI	Q475R	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
ftsI	R504L	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
ftsI	V523M	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
ftsI	V523A	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
ftsI	Y367C	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
ftsI	F533L	-	penicillin-binding protein PBP3 FtsI	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-
nalC	K58E	-	efflux system transcriptional repressor NalC	Pseudomonas aeruginosa	CARBAPENEM	Reference Gene Catalog	-

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Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.

AMR Mutations