A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition.

PMID: 332981602020Germany

Key Findings

The study identifies multiple AMR genes including blaNDM-1, blaCTX-M-15, and blaOXA-48 in K. pneumoniae ST307 isolates, along with mutations in pmrB, pmrA, phoP, pmrC, pmrD, arnT, and ugd contributing to colistin resistance. Additionally, virulence factors such as ybt, iuc, rmpA, and rmpA2 are noted.

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3gene entries

11mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCTX-M	1	beta-lactamase	Cephalosporin	Klebsiella pneumoniae	Reslit	-
blaNDM	1	beta-lactamase	Carbapenem	Klebsiella pneumoniae	Reslit	-
blaOXA	1	beta-lactamase	Carbapenem	Klebsiella pneumoniae

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrA	A41T	-	-	Klebsiella pneumoniae	Colistin	Reslit	-
pmrD	T60M	-	-	Klebsiella pneumoniae	Colistin	Reslit	-
pmrA	I173N	-	-	Klebsiella pneumoniae	Colistin	Reslit

Browse Papers

A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition.

AMR Genes

AMR Mutations