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Key Findings
The study identified several AMR genes and mutations in Enterococcus faecium isolates, including pbp5, vanA, vanB, aac(6')-Ie-aph(2")-Ia, gyrA, parC, tet(L), tet(M), tet(S), and 23S rRNA. These genes and mutations were validated experimentally and showed high accuracy in predicting antimicrobial resistance.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aac(6')-Ie/aph(2'') | 1 | aminoglycoside-modifying enzyme | Gentamicin |
| Reslit | - |
| tet(L) | 1 | tetracycline efflux pump | TetracyclineDoxycycline |
| Reslit | - |
| tet(M) | 1 | ribosomal protection protein | Tetracycline |
|
Reslit |
| - |
| tet(S) | 1 | ribosomal protection protein | TetracyclineDoxycycline |
| Reslit | - |
| vanA | 1 | vancomycin resistance operon | Vancomycin |
| Reslit | - |
| vanB | 1 | vancomycin resistance operon | Vancomycin |
| Reslit | - |
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