Key Findings

The study characterizes the diversity of carbapenemase-producing Escherichia coli isolates in France, identifying key resistance genes such as bla OXA-48, bla OXA-181, bla NDM-1, bla NDM-5, bla VIM-1, bla VIM-4, bla KPC-2, bla KPC-3, and mcr-9. It highlights the role of mutations in ftsI, ompC, gyrA, and parC in reducing susceptibility to β-lactams and fluoroquinolones.