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Explore scientific publications on antimicrobial resistance
Explore scientific publications on antimicrobial resistance
Key Findings
The study characterizes the vanD glycopeptide resistance gene cluster in Enterococcus faecium BM4339, identifying several genes including vanD, vanH, vanX, vanY, vanR, and vanS, which collectively confer resistance to glycopeptide antibiotics through the synthesis of d-alanyl-d-lactate-terminating peptidoglycan precursors.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| vanD | 1 | ligase | GlycopeptideVANCOMYCIN |
| Card DatabaseReference Gene CatalogReslit | - |
| vanH | 1 | dehydrogenase | Glycopeptide |
| Reslit | - |
| vanH-D | 1 | D-lactate dehydrogenase VanH-D |
VANCOMYCIN |
|
Reference Gene Catalog |
| - |
| vanR-A | 1 | regulator | Glycopeptide |
| Reslit | - |
| vanR-D | 1 | vancomycin resistance response regulator transcription factor VanR-D | VANCOMYCIN |
| Reference Gene Catalog | - |
| vanS-A | 1 | sensor | Glycopeptide |
| Reslit | - |
| vanS-D | 1 | vancomycin resistance histidine kinase VanS-D | VANCOMYCIN |
| Reference Gene Catalog | - |
| vanX-A | 1 | dd-dipeptidase | Glycopeptide |
| Reslit | - |
| vanX-D | 1 | D-Ala-D-Ala dipeptidase VanX-D | VANCOMYCIN |
| Reference Gene Catalog | - |
| vanY-A | 1 | dd-carboxypeptidase | Glycopeptide |
| Reslit | - |
| vanY-D | 1 | transpeptidase-like D-Ala-D-Ala carboxypeptidase VanY-D | VANCOMYCIN |
| Reference Gene Catalog | - |
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