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Key Findings
The study reports a pandrug-resistant Acinetobacter pittii isolate (17-84) carrying multiple resistance genes including blaOXA-58, blaPER-1, aph(3')-VIb, aac(3')-IId, sul2, msr(E), and mph(E), along with mutations in gyrA, gyrB, parC, and pmrC contributing to resistance against various antibiotics.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aac(3)-IId | 1 | N-acetyltransferase | Aminoglycoside |
| Reslit | - |
| aph(3')-VIb | 1 | O-phosphotransferase | Aminoglycoside |
| Reslit | - |
| blaOXA | 1 | carbapenem-hydrolyzing class D beta-lactamase | Beta-lactams |
|
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| Q143L | - | mutations in the pmrC gene including Q143L, L146F, Q148K, I171V, and L258S were detected in strain 17-84 and whether these mutations contributed to the colistin resistance phenotype remined to be studied | Acinetobacter pittii | Colistin | Reslit | - | |
| L146F | - | mutations in the pmrC gene including Q143L, L146F, Q148K, I171V, and L258S were detected in strain 17-84 and whether these mutations contributed to the colistin resistance phenotype remined to be studied | Acinetobacter pittii | Colistin | Reslit | - | |
| S81L | - | lower the affinity for quinolone |
Reslit |
| - |
| blaPER | 1 | serine beta-lactamase | Beta-lactams |
| Reslit | - |
| mph(E) | 1 | macrolide phosphotransferase | Macrolide |
| Reslit | - |
| msr(E) | 1 | macrolide ribosome methyltransferase | Macrolide |
| Reslit | - |
| Acinetobacter pittii |
Quinolone |
Reslit |
| - |
| L258S | - | mutations in the pmrC gene including Q143L, L146F, Q148K, I171V, and L258S were detected in strain 17-84 and whether these mutations contributed to the colistin resistance phenotype remined to be studied | Acinetobacter pittii | Colistin | Reslit | - |
| A414T | - | lower the affinity for quinolone | Acinetobacter pittii | Quinolone | Reslit | - |
| I171V | - | mutations in the pmrC gene including Q143L, L146F, Q148K, I171V, and L258S were detected in strain 17-84 and whether these mutations contributed to the colistin resistance phenotype remined to be studied | Acinetobacter pittii | Colistin | Reslit | - |
| Q148K | - | mutations in the pmrC gene including Q143L, L146F, Q148K, I171V, and L258S were detected in strain 17-84 and whether these mutations contributed to the colistin resistance phenotype remined to be studied | Acinetobacter pittii | Colistin | Reslit | - |
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