Prevalence and genetic characterization of clinically relevant extended-spectrum beta-lactamase-producing Enterobacterales in the Gulf Cooperation Council countries.

PMID: 398166442023Gulf Cooperation Council countries|Gulf Cooperation Council|Gulf Cooperation Council region

Key Findings

The study identifies bla CTX-M, bla TEM, and bla SHV as the most prevalent extended-spectrum beta-lactamase (ESBL) genes in Enterobacterales from the Gulf Cooperation Council (GCC) region, contributing to multidrug resistance. Additionally, bla OXA-48 and bla NDM-1 are noted as significant carbapenem-resistance genes.

View on PubMed

6gene entries

7mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCTX-M	1	beta-lactamase	AmpicillinAztreonamCefoxitinCefotaximeCeftriaxoneCeftazidimeCefepime	Escherichia coli Klebsiella pneumoniae	Reslit	-
blaNDM	1	beta-lactamase

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mgrB	Q22P	-	-	Klebsiella pneumoniae	Colistin	Reslit	-
pmrA	G53V	-	-	Klebsiella pneumoniae	Colistin	Reslit	-
pmrB	T157P	-	-	Klebsiella pneumoniae	Colistin	Reslit

Browse Papers

Prevalence and genetic characterization of clinically relevant extended-spectrum beta-lactamase-producing Enterobacterales in the Gulf Cooperation Council countries.

AMR Genes

AMR Mutations