Key Findings

The study identifies several beta-lactamase genes, including blaNDM-13, blaTEM-1B, blaTEM-141, blaCTX-M-55, and blaOXA-1, which confer resistance to aztreonam in the multidrug-resistant E. coli strain ymmD45. The aztreonam-clavulanic acid combination showed synergistic effects in reducing the MIC of aztreonam below its clinical breakpoint.