DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands.

PMID: 228695692012Ireland

Key Findings

The study identifies and characterizes novel SCCmec-SCCM1 composite islands in MRSA isolates, highlighting the presence of various AMR genes such as blaZ, erm(A), aadD, qacA, qacC, merA, merB, fosB, sdrM, aacA-aphD, far1 (fusB), Q6GD50 (fusC), and cat-pC194 (pMC524).

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9gene entries

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
apha3	1	Aminoglycoside modifying enzyme	KanamycinNeomycin	Staphylococcus aureus	Reslit	-
catA1	1	Chloramphenicol acetyltransferase	Chloramphenicol	Staphylococcus aureus	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
fusA	L461K	-	-	Staphylococcus aureus	Fusidic acid	Reslit	-

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AMR Genes

AMR Mutations