Use of Molecular Methods To Detect Shigella and Infer Phenotypic Resistance in a Shigella Treatment Study.

PMID: 346694562022Bangladesh

Key Findings

The study identified several AMR genes including ermB, mphA, blaTEM, blaCTX-M1, blaDHA, blaOXA-1, dfrA, and sul in Shigella isolates. Mutations in gyrA (83L) and parC (80I) were associated with ciprofloxacin resistance.

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8gene entries

4mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCTX-M	1	extended-spectrum beta-lactamase	Ampicillin	Shigella sonnei Shigella flexneri	Reslit	-
blaDHA	1	beta-lactamase	Ampicillin	Shigella sonnei Shigella flexneri	Reslit	-
blaOXA	1	beta-lactamase	Ampicillin

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	I80N	-	-	Shigella sonnei, Shigella flexneri	Ciprofloxacin	Reslit	-
gyrA	L83F	-	-	Shigella flexneri, Shigella sonnei	Ciprofloxacin	Reslit	-

Browse Papers

Use of Molecular Methods To Detect Shigella and Infer Phenotypic Resistance in a Shigella Treatment Study.

AMR Genes

AMR Mutations