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Explore scientific publications on antimicrobial resistance
Explore scientific publications on antimicrobial resistance
Key Findings
The study characterizes the first recognized outbreak of NDM-1-producing K. pneumoniae in Portugal, highlighting the introduction of a new ST11 KL105 strain carrying blaNDM-1 in a unique genetic context. Several antibiotic resistance genes, including blaNDM-1, blaCTX-M-15, and others, were identified, along with chromosomal mutations conferring reduced susceptibility to fluoroquinolones and fosfomycin.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aac(3)-IId | 1 | aminoglycoside acetyltransferase | Aminoglycoside |
| Reslit | - |
| aac(6')-Ib-cr | 1 | aminoglycoside acetyltransferase | Aminoglycoside |
| Reslit | - |
| aph(3'')-Ib | 1 | adenine phosphotransferase | Aminoglycoside |
|
Reslit |
| - |
| aph(6)-Id | 1 | adenine phosphotransferase | Aminoglycoside |
| Reslit | - |
| blaCTX-M | 1 | beta-lactamase | Beta-lactams |
| Reslit | - |
| blaNDM | 1 | carbapenemase | Carbapenem |
| Reslit | - |
| catB3 | 1 | chloramphenicol acetyltransferase | Chloramphenicol |
| Reslit | - |
| dfrA14 | 1 | dihydrofolate reductase | Trimethoprim |
| Reslit | - |
| oqxab | 1 | efflux pump | Quinolone |
| Reslit | - |
| qnrB | 1 | quinolone resistance protein | Fluoroquinolone |
| Reslit | - |
| sul2 | 1 | sulfonamide resistance protein | Sulfonamide |
| Reslit | - |
| tet(D) | 1 | tetracycline resistance protein | Tetracycline |
| Reslit | - |
| - |
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