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Key Findings
ExoU isolates of Pseudomonas aeruginosa exhibited higher resistance to fluoroquinolones and aminoglycosides compared to exoS isolates, primarily due to mutations in gyrA, parC, and efflux pump-related genes, as well as the presence of acquired resistance genes aph(3''-Ib) and aph(6)-Id.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aph(3'')-Ib | 1 | aminoglycoside phosphotransferase | GentamicinTobramycin |
| Reslit | - |
| aph(6)-Id | 1 | aminoglycoside phosphotransferase | GentamicinTobramycin |
| Reslit | - |
| - |
| A30T | - | - | Pseudomonas aeruginosa | Gentamicin|Tobramycin | Reslit | - |
| E251Q | - | - | Pseudomonas aeruginosa | LevofloxacinCiprofloxacin|Levofloxacin | Reslit | - |
| G589A | - | - | Pseudomonas aeruginosa | Gentamicin|Tobramycin | Reslit | - |
| T83I | - | reduction of the binding affinity of fluoroquinolones to DNA gyrase leading to reduced susceptibility | Pseudomonas aeruginosa | Ciprofloxacin|Levofloxacin | Reslit | - |
| G957D | - | - | Pseudomonas aeruginosa | Ciprofloxacin|Levofloxacin | Reslit | - |
| S8F | - | - | Pseudomonas aeruginosa | Ciprofloxacin|Levofloxacin | Reslit | - |
| S170N | - | - | Pseudomonas aeruginosa | Gentamicin|Tobramycin | Reslit | - |
| V1042A | - | - | Pseudomonas aeruginosa | Ciprofloxacin|Levofloxacin | Reslit | - |
| D79E | - | - | Pseudomonas aeruginosa | Ciprofloxacin|Levofloxacin | Reslit | - |
| A262E | - | - | Pseudomonas aeruginosa | LevofloxacinCiprofloxacin|Levofloxacin | Reslit | - |
| Q840E | - | - | Pseudomonas aeruginosa | Gentamicin|Tobramycin | Reslit | - |
| G89S | - | - | Pseudomonas aeruginosa | Gentamicin|Tobramycin | Reslit | - |
| A277T | - | - | Pseudomonas aeruginosa | LevofloxacinCiprofloxacin|Levofloxacin | Reslit | - |
| N1036T | - | - | Pseudomonas aeruginosa | Gentamicin|Tobramycin | Reslit | - |
| T87S | - | - | Pseudomonas aeruginosa | Levofloxacin | Reslit | - |
| V73A | - | - | Pseudomonas aeruginosa | Ciprofloxacin|Levofloxacin | Reslit | - |
| L153R | - | - | Pseudomonas aeruginosa | Gentamicin|TobramycinGentamicin | Reslit | - |
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