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Key Findings
The study identified several AMR genes and mutations in P. aeruginosa and K. pneumoniae isolates from wastewater samples in Kumasi, Ghana, highlighting the presence of multidrug-resistant strains carrying genes such as blaCTX-M-15, blaOXA-488, and qnrVC1, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aac(3)-IIe | 1 | aminoglycoside acetyltransferase | Amikacin |
| Reslit | - |
| aac(6')-Ib | 1 | aminoglycoside acetyltransferase | Amikacin |
| Reslit | - |
| aph(3')-IIb | 1 | modifies and inactivates aminoglycosides | Amikacin |
|
Reslit |
| - |
| blaOXA | 2 | beta-lactamase | CarbapenemCephalosporin |
| Reslit | - |
| blaPDC | 1 | beta-lactamase | CarbapenemCephalosporin |
| Reslit | - |
| blaSCO | 1 | beta-lactamase | CarbapenemCephalosporin |
| Reslit | - |
| blaTEM | 1 | beta-lactamase | PenicillinCephalosporin |
| Reslit | - |
| dfrA14 | 1 | dihydrofolate reductase | Trimethoprim |
| Reslit | - |
| floR2 | 1 | fluoroquinolone resistance protein | Tetracycline |
| Reslit | - |
| fosA | 1 | fosfomycin resistance protein | Fosfomycin |
| Reslit | - |
| qnrVC | 1 | quinolone resistance protein | Fluoroquinolone |
| Reslit | - |
| sul1 | 1 | sulfonamide resistance protein | Sulfamethoxazole |
| Reslit | - |
| tmexC | 1 | tigecycline resistance protein | Tigecycline |
| Reslit | - |
| tmexD | 1 | tigecycline resistance protein | Tigecycline |
| Reslit | - |
| toprJ | 1 | tigecycline resistance protein | Tigecycline |
| Reslit | - |
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