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Key Findings
The study identifies various AMR genes and mutations in Neisseria gonorrhoeae that contribute to resistance against multiple antibiotics, including cefixime, penicillin, azithromycin, ciprofloxacin, and tetracycline. These findings are supported by WGS and multivariate linear regression models.
| - |
| mef(A) | 1 | efflux pump | Azithromycin |
| Reslit | - |
| mtrR | 1 | transcriptional regulator | CefiximePenicillinAzithromycinTetracycline |
| Reslit | - |
| norM | 1 | efflux pump | Ciprofloxacin |
| Reslit | - |
| penA | 1 | penicillin-binding protein 2 | Cefixime |
| Reslit | - |
| pilQ | 1 | secretin | CefiximePenicillin |
| Reslit | - |
| tet(M) | 1 | tetracycline resistance protein | Tetracycline |
| Reslit | - |
| L421P |
| - |
| - |
| Neisseria gonorrhoeae |
Cefixime|Penicillin |
Reslit |
| - |
| S87R | - | - | - | Ciprofloxacin | Reslit | - |
| A311V | - | - | - | Cefixime | Reslit | - |
| N512Y | - | - | - | Cefixime | Reslit | - |
| H541N | - | - | - | Cefixime | Reslit | - |
| I566V | - | - | - | Cefixime | Reslit | - |
| E666K | - | - | - | Cefixime|Penicillin | Reslit | - |
| S88P | - | - | - | Ciprofloxacin | Reslit | - |
| I312M | - | - | - | Cefixime | Reslit | - |
| G545S | - | - | - | Cefixime | Reslit | - |
| P551S | - | - | - | Cefixime | Reslit | - |
| A574V | - | - | - | Cefixime | Reslit | - |
| S91F | - | - | - | Ciprofloxacin | Reslit | - |
| E91K | - | - | - | Ciprofloxacin | Reslit | - |
| V316T | - | - | - | Cefixime | Reslit | - |
| A501P | - | - | - | Cefixime | Reslit | - |
| P551L | - | - | - | Cefixime | Reslit | - |
| A501V | - | - | - | Cefixime | Reslit | - |
| D95N | - | - | - | Ciprofloxacin | Reslit | - |
| V57M | - | reduced affinity of 30S ribosome for tetracycline | Neisseria gonorrhoeae | Tetracycline | Reslit | - |
| V316P | - | - | - | Cefixime | Reslit | - |
| F504L | - | - | - | Cefixime | Reslit | - |
| P552V | - | - | - | Cefixime | Reslit | - |
| A39T | - | - | - | Cefixime|Penicillin|Azithromycin|Tetracycline | Reslit | - |
| D95G | - | - | - | Ciprofloxacin | Reslit | - |
| T483S | - | - | - | Cefixime | Reslit | - |
| A510V | - | - | - | Cefixime | Reslit | - |
| K555Q | - | - | - | Cefixime | Reslit | - |
| G45D | - | - | - | Cefixime|Penicillin|Azithromycin|Tetracycline | Reslit | - |
| - | - | - | Cefixime|Penicillin|Azithromycin|Tetracycline | Reslit | - |
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