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Key Findings
The study identifies bla(VIM-2) and bla(KPC-2) genes in multidrug-resistant Pseudomonas aeruginosa isolates from Colombia, highlighting their diverse genetic environments and mechanisms of resistance.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aac(6')-Ib | 1 | aminoglycoside acetyltransferase | Aminoglycoside |
| Reslit | - |
| aac(6')-Ib-cr | 1 | aminoglycoside acetyltransferase | Aminoglycoside |
| Reslit | - |
| ant(2'')-Ia | 1 | aminoglycoside nucleotidyltransferase | Aminoglycoside |
Reslit |
| - |
| aph(3'')-Ib | 1 | aminoglycoside phosphotransferase | Aminoglycoside |
| Reslit | - |
| aph(6)-Id | 1 | aminoglycoside phosphotransferase | Aminoglycoside |
| Reslit | - |
| blaKPC | 1 | beta-lactamase | Carbapenem |
| Reslit | - |
| blaVIM | 1 | metallo-beta-lactamase | Carbapenem |
| Reslit | - |
| catB7 | 1 | chloramphenicol acetyltransferase | Chloramphenicol |
| Reslit | - |
| fosA | 1 | fosfomycin resistance protein | Fosfomycin |
| Reslit | - |
| sul1 | 1 | sulfonamide resistance protein | Sulfonamide |
| Reslit | - |
| tet(C) | 1 | tetracycline resistance protein | Tetracycline |
| Reslit | - |
| - |
| D83E | - | - | Pseudomonas aeruginosa | Cefepime|Gentamicin|Ciprofloxacin | Reslit | - |
| S87L | - | - | Pseudomonas aeruginosa | Fluoroquinolones | Reslit | - |
| R43Q | - | - | Pseudomonas aeruginosa | Imipenem|Meropenem|Ciprofloxacin | Reslit | - |
| L71R | - | - | Pseudomonas aeruginosa | Colistin | Reslit | - |
| T105A | - | more efficient carbapenem and cefepime hydrolysis | Pseudomonas aeruginosa | Ceftazidime|Aztreonam | Reslit | - |
| A501V | - | - | Pseudomonas aeruginosa | Cefepime|Gentamicin|Ciprofloxacin | Reslit | - |
| S2P | - | - | Pseudomonas aeruginosa | Colistin | Reslit | - |
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