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Key Findings
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| aac(3)-IId | 1 | aminoglycoside acetyltransferase | GentamicinKanamycinTobramycin |
| Reslit | - |
| aadA | 1 | adenine phosphotransferase | StreptomycinSpectinomycin |
Reslit |
| - |
| aph(3'')-Ib | 1 | aminoglycoside phosphotransferase | GentamicinKanamycinTobramycin |
| Reslit | - |
| blaCTX-M | 4 | beta-lactamase | CefotaximeCeftazidimeCefepime |
| Reslit | - |
| blaOXA | 1 | beta-lactamase | AmpicillinCefoxitin |
| Reslit | - |
| blaTEM | 2 | beta-lactamase | AmpicillinCefoxitin |
| Reslit | - |
| catA1 | 1 | chloramphenicol acetyltransferase | Chloramphenicol |
| Reslit | - |
| dfrA1 | 1 | dihydrofolate reductase | Trimethoprim |
| Reslit | - |
| dfrA12 | 1 | dihydrofolate reductase | Trimethoprim |
| Reslit | - |
| dfrA14 | 1 | dihydrofolate reductase | Trimethoprim |
| Reslit | - |
| dfrA17 | 1 | dihydrofolate reductase | Trimethoprim |
| Reslit | - |
| sul1 | 1 | sulfonamide resistance protein | Sulfamethoxazole |
| Reslit | - |
| sul2 | 1 | sulfonamide resistance protein | Sulfamethoxazole |
| Reslit | - |
| tetA | 1 | tetracycline efflux pump | Tetracycline |
| Reslit | - |
| tetB | 1 | tetracycline efflux pump | Tetracycline |
| Reslit | - |
| - |
| - |
CiprofloxacinCiprofloxacin|Levofloxacin |
Reslit |
| - |
| D87G | - | - | CiprofloxacinCiprofloxacin|Levofloxacin | Reslit | - |
| S80I | - | Shigella flexneri | CiprofloxacinCiprofloxacin|Levofloxacin | Reslit | - |
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